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These changes can be subtle and may not be obvious without careful observation

Lorestani, S., Bahari, A., Asadi, M., & Zahedi Avval, F

These medications (semaglutide and tirzepatide) are injected once weekly and produce 10-22% average body weight loss by reducing hunger, increasing feelings of fullness, and slowing digestion

(CPS)" In summary, all three guidelines agree that SGLT2 inhibitors should be discontinued for at least 3 days preoperatively, with the main concern being the prevention of DKA/euglycemic DKA and metabolic acidosis due to increased ketone production

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Take tirzepatide first, where Willards pharmacology work in JCI Insight shows the molecule, LY3298176, turning on both the GIP and GLP-1 receptors